Abstract
Problem Dalton’s lymphoma (DL) shows very high interleukin (IL)‐13 level in the serum and ascitic fluid. Therefore, in the present study, we investigated if any sexual dichotomy in the level of IL‐13, and resulting B‐cell activation and Ig subclass switching also exist in the tumor‐bearing host.Method of study Serum and ascitic fluid of different groups of DL‐bearing mice were isolated and IL‐13 level and various Ig levels in serum were quantified by double‐sandwich enzyme‐linked immunosorbent assay. Further, the B cells were isolated from DL‐bearing mice and effects of various concentrations of IL‐13 and sex steroids were measured.Results Uncastrated and hormone replaced DL‐bearing mice showed sexual dichotomy in IL‐13 level, and subsequent difference in Ig‐level and this was found to be more pronounced in females. Similarly, in vitro study suggested that estrogen treatment, in combination with IL‐13, strongly modulates B‐cell Ig switching in comparison to testosterone treatment in association with IL‐13.Conclusion It can be concluded that IL‐13, in concert with gonadal hormones, differentially modulates the B‐cell function in a tumor‐bearing host.
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