Abstract
Total activity and isoenzyme pattern of lactate dehydrogenase was determined in synovial tissue, synovial fluid and synovial fluid leucocytes in eleven patients with rheumatoid arthritis. All three tissue specimens were obtained from the same patient in connection with synovectomy operations. Total LDH activity in synovial fluid did not significantly correlate with the fluid leucocyte count. The LDH isoenzymes in the three tissue components were mainly cathodic. Similar distribution of LDH 3, LDH 4 and LDH 5 was observed in synovial fluid and fluid leucocytes, with highest activity in LDH 5. However, the isoenzyme distribution in synovial tissue differed from that in synovial fluid and fluid cells, the isoenzymes LDH 4 and LDH 5 having almost equal activity. In synovial fluid small amounts of LDH 1 could be found which is suggested to be derived from serum. The results suggest that the main part of the LDH activity known to be increased in rheumatoid synovial fluid is derived from disruption of leucocytes, abundantly present in the fluid of diseased joint.
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