Origin of sympathetic efferent axons in the renal nerves of the cat

Abstract

The origin of efferent axons in the renal nerves of the cat was examined using retrograde transport of horseradish peroxidase (HRP). Nerves on the surface of the left renal blood vessels were dissected 5–7 mm proximal to the medial margin of the kidney, transected and the central cut ends exposed to HRP. Labeled neurons were typically identified in three locations: (1) centrally along the renal nerve, (2) in the superior mesenteric ganglion, and (3) in the ipsilateral sympathetic chain ganglia (T12-L3). HRP was not detected in preganglionic neurons in the thoracolumbar spinal cord. Labeled cells ranged in size from 15 to 50 μm, with those in the renal nerve at the smaller end of the spectrum and those in the superior mesenteric ganglion at the larger end. In the superior mesenteric ganglion labeled cells were typically localized to a small region in the caudal pole of the ganglion around the origin of the renal nerve. The results show that the sympathetic efferent innervation of the kidney is derived from both paravertebral and prevertebral ganglia. In the latter (superior mesenteric ganglion), renal efferent neurons exhibited a topographic distribution.