Abstract
It is generally agreed at present that the early rise of plasma and urinary serotonin (5-HT) levels caused by moderate doses of ionizing irradiation are due to a release of 5-HT from the body stores (ALTMAN et coll. 1970, STREFFER 1969). For practical purposes, i.e. for the localization of injury after radiation accidents more or less specific biochemical indicators are of meaningful value (Biochem. Indicators of Radiation Injury in Man); 5-HT has been mentioned as such. It therefore appeared worthwhile to investigate the origin of the 5-HT present in body fluids after exposure to several types of ionizing irradiation. 5-HT is bound to subcellular structures in various tissues throughout the body; significant quantities occur in the brain, lungs, liver, intestinal tract, spleen, skin and blood platelets ( GARATTINI & VALZELLI 1965). Partial body irradiation has enabled a number of these organs to be examined as being the possible potential sources of the 5-HT released into the blood plasma; the experiments were mainly executed with moderate doses of roentgen irradiation; a few were carried out with 14 MeV neutron irradiation. All indicated the intestinal tract as the principal site of origin for the enhanced amount of free 5-HT in the circulation. Methods. Random bred Chinchilla rabbits of about 3 kg and institute inbred grey mice weighing between 20 and 30 g were used. The rabbits were individually
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