Abstract
THE origin of plasma cells in inflammatory reactions in non-lymphoid tissue is perplexing. They are found in the circulation only in unusual circumstances1 and are not a usual cellular component of normal connective tissue. A possible source of these cells in areas of injury is suggested from investigations of lymphocytic cells in the vascular spaces and alveolar walls of the lung following the intravenous injection of complete Freund's adjuvant. The changes in some of these lymphocytes are similar to those described for white cells of the peripheral blood grown in tissue culture in the presence of a variety of materials. When phytohæmagglutinin, tuberculin, tetanus toxoid, diphtheria toxoid, smallpox vaccine, hæmophilus pertussis antigen, staphylococcal antigen, leukocyte antiserum, pollen extract and various tissue antigens are added to cultures of white cells from the peripheral blood, the small and medium sized lymphocytes enlarge and mitotic division may occur2–13. Tanaka et al.14 have described a developing Golgi apparatus, increased ribosomes and a small amount of endoplasmic reticulum in cultures of lymphocytes from peripheral blood.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
