Abstract
Cells producing normal antibodies against sheep's erythrocytes were revealed by local hemolysis in agar in the spleen of embryos in the late stage of development and of newborn guinea pigs. Preliminary immunization of the pregnant animals with sheep's red cells did not affect the number of hemolysin-producing cells in the spleen of the embryos or newborn guinea pigs. The number of normal antibody-forming cells in the spleen of sterile adult guinea pigs was the same as in animals of the same species kept under ordinary conditions. The results suggest that normal hemolysin-producing cells arise in guinea pigs not by antigenic stimulation through cross-reacting antigens of the external environment, but by physiological differentiation of predetermined precursor cells. This hypothesis corresponds to one of the postulates of the clonal selection theory of immunogenesis.
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