Abstract

Defective interfering virus (DI) particles represent a major controlling element of virus replication. They are constantly generated at low levels by infectious virus and only amplify to interfering levels when the parent helper vims is abundant. This autointerference phenomenon, as it was called when first discovered, is achieved by rearrangements and deletions of the standard virus genome such that the resulting “incomplete form” of the virus can preferentially replicate.KeywordsVesicular Stomatitis VirusSemliki Forest VirusSindbis VirusMinus StrandInternal DeletionThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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