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Abstract
Early telencephalic development involves the migration of diverse cell types that can be identified by specific molecular markers. Most prominent among them are Cajal-Retzius (CR) cells that emanate mainly from the cortical hem and to a lesser extent from rostrolateral, septal and caudo-medial regions. One additional territory proposed to give rise to CR cells that migrate dorsally into the neocortex lies at the ventral pallium, although contradictory results question this notion. With the use of a cell-permeable fluorescent tracer in cultured embryos, we identified novel migratory paths of putative CR cells and other populations that originate from the rostrolateral telencephalon at its olfactory region. Moreover, extensive labeling on the lateral telencephalon along its rostro-caudal extent failed to reveal a dorsally-migrating CR cell population from the ventral pallium at the stages analyzed. Hence, this work reveals a novel olfactory CR cell migration and supports the idea that the ventral pallium, where diverse types of neurons converge, does not actually generate CR cells.
Highlights
Corticogenesis is characterized by extensive cellular migration, both radial (from the ventricular zone (VZ) towards the pial surface) and tangential
Labeled sites at a rostral lateral domain (Rld) adjacent to the prospective OB territory (Figure 1A, black dots) generated cells that migrated in two main directions (Figure 1A, arrows)
We were able to confirm that CFDA was applied in the VZ (Figure 1C, asterisk) of the Rld, from where labeled cells migrated radially to the pial side of the telencephalic vesicle followed by tangential displacement
Summary
Corticogenesis is characterized by extensive cellular migration, both radial (from the ventricular zone (VZ) towards the pial surface) and tangential (along the pial surface; Marin and Rubenstein, 2001). Cajal-Retzius (CR) cells are one of the earliest neuronal types to be born at focal sites surrounding the cortical epithelium, from where they migrate tangentially to quickly populate the entire cortex. Presumptive olfactory regions of the cortex, including the developing and early postnatal piriform and entorhinal cortices, contain subsets of neurons that are strikingly similar to the CR neurons found in the neocortex (Meyer et al, 2004; Yamazaki et al, 2004). We confirmed previous studies and added novel information about the complex patterns of olfactory CR neuron development
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