Abstract
Background The intraflagellar transport (IFT) complex is an ancient protein complex that facilitates active trafficking of proteins and molecules across the eukaryotic cilium. Based on similar domain compositions Avidor-Reiss et al. (2004) and Jekely et al. (2006) postulated that the IFT originates from an ancestral proto-coatomer complex that also gave rise to vesicle coating complexes (e.g. COPI, COPII, Clathrin) and the Nuclear Pore Complex. Using comparative genomics we provide direct phylogenetic evidence of the proto-coatomer origin of the IFT.
Highlights
The intraflagellar transport (IFT) complex is an ancient protein complex that facilitates active trafficking of proteins and molecules across the eukaryotic cilium
Based on similar domain compositions Avidor-Reiss et al (2004) and Jékely et al (2006) postulated that the IFT originates from an ancestral proto-coatomer complex that gave rise to vesicle coating complexes (e.g. COPI, COPII, Clathrin) and the Nuclear Pore Complex
Using comparative genomics we provide direct phylogenetic evidence of the proto-coatomer origin of the IFT
Summary
The intraflagellar transport (IFT) complex is an ancient protein complex that facilitates active trafficking of proteins and molecules across the eukaryotic cilium. Origin and extension of the IFT complex in early eukaryotic evolution J van Dam1*, MC Field2, M Huynen1 From First International Cilia in Development and Disease Scientific Conference (2012) London, UK.
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