Abstract
The distribution of norepinephrine (NE) was chemically mapped in discrete regions of the rat habenula (Hb). In addition, the contribution of both peripheral sympathetic and central noradrenergic sources to habenula NE was quantified following selective deafferentations. It was found that NE is distributed hetereogeneously in discrete Hb regions. Furthermore, it was demonstrated that after superior cervical ganglionectomy a small (26%) but significant (P<0.05) decrease in NE occurred only in the medial Hb (MHb), while NE in the lateral Hb (LHb) remained unaltered. In contrast, deafferentation of central noradrenergic innervation, such as lesions in the ascending dorsal noradrenergic bundle (DNB), caused a marked decrease in NE in both MHb (53%) and LHb (50%). Lesioning the dorsal longitudinal fasciculus resulted in NE loss in both MHb and LHb by 31%. These data corroborate the histofluorescent demonstration of the noradrenergic innervation of the Hb.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
