Abstract
Cell Biology Adherent cells position their spindle poles parallel to the plane of the substrate and orient the spindle within that plane according to cell shape–dependent mechanical forces. Anastasiou et al. found that proper spindle positioning in cultured cells was supported by integrin-mediated cell–extracellular matrix adhesion. Adhesion-dependent integrin activation was not required to position spindles parallel to the substrate plane, but force-dependent integrin activation was required to orient spindles in response to mechanical cues generated by adhesion topology. Sci. Signal. 13 , eaax9940 (2020).
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