Abstract
The aim of this study is to investigate how elevation of body temperature changes organs blood flow during sevoflurane anesthesia. We conducted in vivo research on 14 male Wistar rats to monitor pulse rate and arterial blood pressure and measure hepatic, small intestinal, renal, and descending aortic blood flow using a laser Doppler blood flowmeter. We assessed the changes in organ blood flow, pulse rate, and arterial blood pressure during elevation of the rats' body temperatures up to 41.5°C under anesthesia with 2.0% or 3.0% sevoflurane. We concluded that elevation of body temperature up to 39.5°C does not change hepatic, small intestinal, and renal blood flow during 2.0 and 3.0% sevoflurane anesthesia.
Highlights
After the surgical procedure and the local anesthesia, the rats were allowed to recover from them on a temperaturecontrolled mat for 1 hour under 2.0% sevoflurane anesthesia
There was no significant difference between 2.0% and 3.0% sevoflurane anesthesia in pulse rate, mean arterial blood pressure, and each blood flow value
Pulse rate was maintained up to 39.5∘ C of body temperature under 2.0% sevoflurane anesthesia but increased thereafter (Figure 1)
Summary
Perturbations in body temperature induce marked changes in heart rate, arterial blood pressure, and organ blood flow via sympathetic nervous activation. High body temperature induces increases in splanchnic, renal, splenic, and lumbar sympathetic nerve activity [1, 2], resulting in constriction of the respective vascular beds and reduction in blood flow. High body temperature elicits vasodilation of skin vasculature [3, 4]. Hyperthermia leads to redistribution of blood flow. For example, sevoflurane, induce changes in organ blood flow [5] with decreasing sympathetic nervous activity [6]
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