Abstract
Oesophagectomy is part of the mainstay of treatment for oesophageal cancer. Because most affected patients are elderly and have associated comorbidities, surgery is challenging. Furthermore, recovery from surgery can take up to a year and, in view of the poor survival associated with this cancer type, many patients will not regain their preoperative quality of life. 1 Smyth EC Lagergren J Fitzgerald RC et al. Oesophageal cancer. Nat Rev Dis Primers. 2017; 3: 17048 Crossref PubMed Scopus (294) Google Scholar Detection of residual disease after neoadjuvant chemoradiotherapy for oesophageal cancer (preSANO): a prospective multicentre, diagnostic cohort studyAfter neoadjuvant chemoradiotherapy for oesophageal cancer, clinical response evaluation with endoscopic ultrasonography, bite-on-bite biopsies, and fine-needle aspiration of suspicious lymph nodes was adequate for detection of locoregional residual disease, with PET–CT for detection of interval metastases. Active surveillance with this combination of diagnostic modalities is now being assessed in a phase 3 randomised controlled trial (SANO trial; Netherlands Trial Register NTR6803). Full-Text PDF
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