Organosilane as a versatile compound: Silica-Based nanoparticles for detection of methyl parathion and inhibition of acetylcholinesterase (AChE) in Alzheimer’s disease

Abstract

In this article, we sketched and synthesized chalcone appended triazole organosilane (TP), and it was thoroughly characterised using NMR (1H and 13C) and mass spectrometry. Furthermore, TP was immobilized over the silica nanoparticles (TP-NPs) utilizing one-pot strategy, and TP-NPs were thoroughly characterised using various techniques including FT-IR, XRD, EDX, FE-SEM, and TGA. TP-NPs were found to be very sensitive and selective towards detection of methyl parathion (MP) over other tested ions by both UV–Visible and fluorescence spectroscopy, with values of limit of detection as low as 3.83 X 10−9 M and 5.76 X 10−10 M, respectively. TP-NPs has high surface area and have various functional group present on the surface which aid in the detection of MP; nitrogens of the triazole moiety have high affinity for phosphorous atom in MP while Si atom interacts with the oxygen present in the MP, facilitating the sensing of MP by TP-NPs. Additionally, in silico docking studies showed that TP exhibits a good inhibitory response to the human acetylcholinesterase (AChE) protein, making it a potential candidate against Alzheimer’s disease (AD). Also, the real sample analyses of methyl parathion in agricultural soil and water samples were successfully done with excellent recovery rates, ranging from 92.25% to 109%, respectively.