Abstract
In recent years, there has been a significant increase in the clinical use of organometallic compounds and metal complexes for therapeutic purposes including treatment of inflammatory bowel diseases (IBD). Their action is based on the inhibition of the inflow of pro-inflammatory cytokines, the elimination of free radicals or the modulation of intestinal microbiota. In addition, these compounds are intended for use in the diagnosis and treatment of colorectal cancer (CRC) which is often a consequence of IBD. The aim of this study is to critically discuss recent findings on the use of organometallic compounds and metal complexes in the treatment of IBD and CRC and suggest future trends in drug design.
Highlights
Inflammation is a natural reaction of the body in response to tissue damage, caused mainly by chemical and physical factors [1]
Molecules secreted by macrophages such as nitric oxide (NO) contribute to intensification of the inflammatory process [5]
Critical evaluation of available literature strongly suggests that the future and cancer
Summary
Inflammation is a natural reaction of the body in response to tissue damage, caused mainly by chemical and physical factors [1]. Intestinal inflammation mediated by the immune system is the most important feature in the development of inflammatory bowel diseases (IBD) [3]. It can be triggered by stimulation with lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1). After initiation of the inflammatory process, the production of cytokines and other mediators of inflammation increases through activated macrophages [4]. The main intracellular pathways associated with the development of inflammation include transcription factors signal transducer and activator of transcription 3 (STAT3)
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