Abstract
Organometallic Ru(II), Os(II) and Rh(III) complexes of lapachol induce apoptosis in human tumour cell lines in the low μM range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.
Highlights
Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity†
RuII(arene) complexes have clearly emerged as highly promising candidates to overcome the disadvantages of clinically-used platinum drugs.[10]
The organometallic complexes 1a–c were synthesised by deprotonating commercially available lapachol L with NaOMe followed by conversion with the respective dimer [MCl2(arene)]2 (M = RuII 1a, OsII 1b, RhIII 1c; arene = Z6-p-cymene for RuII, OsII and Z5-pentamethylcyclopentadiene for RhIII) to the corresponding organometallics 1a–c in good to excellent yields (75–96%)
Summary
Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity†. Organometallic RuII, OsII and RhIII complexes of lapachol induce apoptosis in human tumour cell lines in the low lM range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.
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