Abstract
The Janus kinase (JAK) signal transducer and activator of transcription (STAT) pathway is one of the main signaling pathways in eukaryotic cells. This pathway is used during diverse growth and developmental processes in multiple tissues to control cell proliferation, differentiation, survival, and apoptosis. In addition to its role during development, the JAK/STAT pathway has also been implicated in tumorigenesis. Drosophila melanogaster is a powerful genetic tool, and its eyes have been used extensively as a platform to study signaling pathways. Many reports have demonstrated that the JAK/STAT pathway plays pleiotropic roles in Drosophila eye development. Its functions and activation are decided by its interplay with other signal pathways and the epigenetic status. In this review, we focus on the functions and regulation of the JAK/STAT pathway during eye development and provide some insights into the study of this pathway in tumorigenesis. Developmental Dynamics 239:2522–2533, 2010. © 2010 Wiley-Liss, Inc.
Highlights
Organogenesis is controlled by multiple processes such as cell growth, proliferation, and differentiation
Induction of hop mutant clones and upd overexpression clones during early eye development results in inversions of ommatidial orientation. These findings suggest that the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in the determination of polarity
The epistatic analyses demonstrated that the JAK/STAT pathway possibly induces growth upstream from the Notch/ Eyg pathway. These findings suggest that the activation of JAK/STAT pathway is regulated by Notch/Eyg signaling
Summary
Organogenesis and Tumorigenesis: Insight From the JAK/STAT Pathway in the Drosophila Eye. The Janus kinase (JAK) signal transducer and activator of transcription (STAT) pathway is one of the main signaling pathways in eukaryotic cells. The Janus kinase (JAK) signal transducer and activator of transcription (STAT) pathway is one of the main signaling pathways in eukaryotic cells This pathway is used during diverse growth and developmental processes in multiple tissues to control cell proliferation, differentiation, survival, and apoptosis. In addition to its role during development, the JAK/STAT pathway has been implicated in tumorigenesis. Many reports have demonstrated that the JAK/STAT pathway plays pleiotropic roles in Drosophila eye development. We focus on the functions and regulation of the JAK/STAT pathway during eye development and provide some insights into the study of this pathway in tumorigenesis.
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