Abstract
Amphiphilic PNiPAAm- b-PTMC were synthesized by ring-opening polymerization of trimethylene carbonate (TMC) initiated by hydroxyl-terminated poly( N-isopropylacrylamide) (PNiPAAm) as the macroinitiator with the organocatalyst 1,5,7-triazabicyclo-[4.4.0]dec-5-ene (TBD). PNiPAAm- b-PTMC solutions had lower critical solution temperature (LCST) that depended on polymer composition and the solution media. The block copolymers form micelles in the aqueous phase with core–shell structure. Transmission electron microscopy analysis of micelle morphology revealed a spherical structure. Observations and determinations show high drug entrapment efficiency and drug-loading content for these drug micelles.
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