Abstract
Direct substitution of alcohols has been a popular topic in organic chemistry. Deoxyhalogenation of alcohols represents one of the most important transformations for accessing organic halides. However, a practical catalytic protocol with readily available, inexpensive, and stable inorganic halides is still unknown. Herein, we report an organocatalytic deoxyhalogenation of alcohols with inorganic halides, which avoids the employment of stoichiometric activators and organic halogenating reagents. Various alcohols are transformed to the corresponding organic bromides and iodides in good yield. Through the one-pot sequential process, C–N, C–O, C–F, C–Cl, and C–S bond formation can also be achieved with good yield.
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