Abstract
The research groups of MacMillan and Jacobsen have developed examples of organocatalytic carbocyclizations. Rendler and MacMillan employed organo-SOMO catalysis for cyclizations of polyene aldehydes (e.g., 3). Polycycles (e.g., 4) were obtained in good yields and enantioselectivity with 30 mol% of secondary amine catalyst 1. Jacobsen and co-workers developed thiourea catalyst 2 which effects polycyclization of hydroxylactams (e.g., 5). Polycycles (e.g., 6) were obtained in moderate to good yields and enantiomeric ratios up to 97:3.
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