Abstract
Here the authors report an asymmetric direct conjugate addition of 1,3-dicarbonyl compounds to maleimides. Natural cinchona alkaloids quinine or quinidine have been found to be effective for the reaction. With 10-20 mol% of quinine or quinidine both high enantioselectivities (91:9-99:1 er) and diastereoselectivities (84:16 to 98:2 dr) are obtained for different β-keto esters and β-diketones.
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