Abstract
Here the authors report an asymmetric direct conjugate addition of 1,3-dicarbonyl compounds to maleimides. Natural cinchona alkaloids quinine or quinidine have been found to be effective for the reaction. With 10-20 mol% of quinine or quinidine both high enantioselectivities (91:9-99:1 er) and diastereoselectivities (84:16 to 98:2 dr) are obtained for different β-keto esters and β-diketones.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
