Abstract

Organocatalyzed reactions of α,α-difluoro-β-keto esters with acetone were demonstrated. In the presence of L-proline, the Aldol reaction occurred under mild conditions to give the corresponding tertiary α,α-difluoroalcohols in good yields with high enantioselectivities. Using pyrrolidine as catalyst, the domino Michael-aldol reaction took place readily to give the corresponding addition products in high yields with excellent diastereoselectivities.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.