Abstract
A new organocatalytic [2,3] Wittig rearrangement has been reported. Ketones 1 are treated with 20 mol% of pyrrolidine (2) to provide products of type 3 in good yields and syn diastereoselectivities. The reaction presumably proceeds via an enamine intermediate. Furthermore, the first example of an enantioselective version of this sigmatropic reaction has been developed. Chiral secondary amine 5 mediates the rearrangement of allylic ether 4 to the corresponding product 6 in promising yield, enantioselectivity, and diastereoselectivity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
