Abstract
The terminology of “organocatalyst“ discussed in this chapter refers to small chiral organic molecules that catalyze and facilitate asymmetric transformations. The chapter describes two recent applications namely preparation of telcagepant, an application of iminium organocatalysis and preparation of MK-8613, application of asymmetric Michael addition catalyzed by desmethyl quinidine of organocatalysis on an industrial scale at Merck, and also addresses solutions to development issues encountered, from the lab scale to the industrial scale. The idea of what constitutes “large scale” is subjective, but in this context, the industrial scale refers to reactions that have been demonstrated on pilot plant scale and above. Overall, asymmetric organocatalysis is a useful tool in organic synthesis on large scale. Novelty and diversity resulting from the chemistry of asymmetric organocatalysis still continue to expand, and the application of organocatalysis will likely be much broader in the pharmaceutical industry in the future.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
