Abstract
Knoevenagel condensation between carbonyl compounds and active methylene compounds as well as three component Mannich reaction between aldehydes, ketones and amines proceeded smoothly in water with good to excellent yield and high selectivity in the presence of zero and first generation poly(amidoamine) (PAMAM) dendrimers. The products and the catalyst were separated by simple biphasic extraction. The catalyst was found to be reusable.
Highlights
Organocatalysis is the acceleration of chemical reactions with a substoichiometric amount of an organic compound which does not contain a metal atom.[1]
Organocatalysis is an important area of research in recent times because it provides a means for catalyzing reactions in the absence of precious transition metals and a way to mimic nature in the enzyme catalysis which is a basic process of life
Organocatalysis by dendrimers is an emerging area of research due to the environmental friendliness and efficiency of these catalysts.[10]. In this manuscript we describe applications of zero and first generation poly(amidoamine) (PAMAM) dendrimers as organocatalysts
Summary
Organocatalysis is the acceleration of chemical reactions with a substoichiometric amount of an organic compound which does not contain a metal atom.[1]. In this manuscript we report for the first time the applications of PAMAM dendrimers as organocatalysts for Knoevenagel condensation as well as for one-pot three component Mannich reaction in water.
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