Abstract
Gene expression mapping reveals 8 functionally distinct domains in the Xenopus pronephros. Interestingly, no structure equivalent to the mammalian collecting duct is identified.
Highlights
The pronephros, the simplest form of a vertebrate excretory organ, has recently become an important model of vertebrate kidney organogenesis
In the present study we provide complete molecular evidence supporting our model of the segmental organization of the pronephric nephron, we define the physiological functions associated with each nephron segment, and we reveal the extensive analogies with the mammalian metanephric nephron
Genome-wide slc gene expression analysis defines a large panel of pronephric marker genes A genome-scale, whole-mount in situ hybridization screen was performed to evaluate the expression of solute carrier genes during Xenopus pronephric kidney development
Summary
The pronephros, the simplest form of a vertebrate excretory organ, has recently become an important model of vertebrate kidney organogenesis. Along the tubular portion of the mammalian nephron, four main compartments have been identified: proximal tubule, intermediate tubule, distal tubule, and collecting duct. These four structures can be further subdivided into separate segments based on histological criteria [2,3]. The proximal tubules, for instance, return much of the filtrate to the blood circulation in the peritubular capillaries by actively transporting small molecules from the tubular lumen across renal epithelia to the interstitial space, whereas the collecting duct system plays a major role in regulating acid-base balance and urine volume [6,7]
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