Abstract
MCM-41 functionalized by 3-aminopropyltriethoxysilane (APTMS) and 3-chloropropyltriethoxysilane (CPTMS) was synthesized, which had been used to improve the physicochemical properties of mesoporous silica to controlled ibuprofen delivery. Samples were characterized by X-ray diffraction (XRD), N2 adsorption-desorption isotherms and Fourier transform infrared (FT-IR) spectroscopy. Characterized results demonstrated that organic groups were successfully grafted onto the samples, and the mesoporous structure of the synthesized material was maintained. The results of ibuprofen release exhibited that the introduction of CPTMS greatly retarded the ibuprofen release rate, and an accumulative release achieved approximately 13.2 wt% over PClMCM-41 after 32 h. However, the introduction of APTMS greatly promoted the ibuprofen release rate, and the release of ibuprofen could increase to 26.6 wt% over PNH2MCM-41 at 32 h. Those results suggested that ibuprofen release rate could be well modulated by changing the grafted organic group.
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