Organic Diallyl-n-Sulfide (Dn-S) inhibited the glycogenolysis pathway and heart failure of heat-stressed laying hens

Abstract

Heat stress causes a decrease in metabolic and immune function, thus resulting in decreased production. Natural extracts such as the active compound diallyl-n-sulfide (Dn-S) are one strategy to overcome the adverse effects of heat stress. One hundred and fifty female laying hens, with a mean bodyweight of 1191.38±25.54 g, aged 11 weeks, were used in this experiment to study Dn-S’s impact from garlic on the metabolite profile of the glycogenolysis pathway and heart failure in laying hens. The sample of laying hens was divided into five treatment groups, each with 25 samples and the Dn-S from garlic isolated by distillation technique. The study was carried out with three types of experimental treatment, groups with a zone temperature of heat stress (38°C) and without Dn-S, heat stress (38°C) and 100 μL Dn-S/sample, heat stress (38°C) and 1125 μL Dn-S/sample, respectively. Based on the results of the study, it shows that heat stress causes an increase in the rate of glycogenolysis. It appears that the administration of 200 μL Dn-S effectively reduces the rate of glycogenolysis and can maintain a normal heart condition. It was concluded that heat stress in laying hens could be avoided by administering diallyl n-sulfide (Dn-S) from garlic. Dn-S has an essential role in preventing changes in the osmotic pressure of body fluids. Overall, it can cope with the metabolic and physiological changes associated with heat stress.