Abstract
Since, the most susceptible laboratory animal to Foot–and–Mouth disease virus (FMDV) is guinea pig, and then one milliliter of FMDV type (O) concentrations of 106-106.5 TCID50was inoculated intradermally (ID) to 10 plantar surface of guinea pig (right side). Guinea pig adapted virus has been prepared after generalization phase, and then one milliliter of virus was inoculated intradermally to 30 guinea pigs in 5 groups (each consist of six). Samples from different organs including, heart, lung, liver, spleen, pancreas, tongue and plantar epithelium, retropharyngeal and inguinal lymph nodes were collected on days 2, 4, 14, 30, 60 post inoculation (PI) and kept in transport media and sent to FMD department of Ref lab. According to the results of this study, plantar epithelium and tongue as well as lung have been detected to be the original sites for virus survival. In addition, the highest rate of the presence of virus can be seen on 4 days and 14 days PI. By the way there was no sign of presence of the virus in any organs on days 30 and 60 PI.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
