Abstract
Organic bioelectronics forms the basis of conductive polymer tools with great potential for application in biomedical science and medicine. It is a rapidly growing field of both academic and industrial interest since conductive polymers bridge the gap between electronics and biology by being electronically and ionically conductive. This feature can be employed in numerous ways by choosing the right polyelectrolyte system and tuning its properties towards the intended application. This review highlights how active organic bioelectronic surfaces can be used to control cell attachment and release as well as to trigger cell signaling by means of electrical, chemical or mechanical actuation. Furthermore, we report on the unique properties of conductive polymers that make them outstanding materials for labeled or label-free biosensors. Techniques for electronically controlled ion transport in organic bioelectronic devices are introduced, and examples are provided to illustrate their use in self-regulated medical devices. Organic bioelectronics have great potential to become a primary platform in future bioelectronics. We therefore introduce current applications that will aid in the development of advanced in vitro systems for biomedical science and of automated systems for applications in neuroscience, cell biology and infection biology. Considering this broad spectrum of applications, organic bioelectronics could lead to timely detection of disease, and facilitate the use of remote and personalized medicine. As such, organic bioelectronics might contribute to efficient healthcare and reduced hospitalization times for patients.
Highlights
Over the last decade, organic bioelectronics have become more popular and widely used in biological research and medicine [1,2,3,4]
This review demonstrates the most recent developments in organic bioelectronics with important implications for biological research and medicine
A linear gradient of mesenchymal fibroblasts and fibroblast cell lines was generated on an organic electrochemical transistor (OECT) channel with PEDOT:tosylate deposited on top of indium tin oxide (ITO) [131]
Summary
Organic bioelectronics have become more popular and widely used in biological research and medicine [1,2,3,4]. Organic bioelectronics are based on conductive polymers and inherit their flexibility, optical transparency and electrical and ionic conductivity. They can be adapted and functionalized in a wide variety of ways thanks to organic chemistry methods. Conducting polymers act like ionic complexes and their properties are largely dependent on the conjugated backbone, redox state and doping agent [15]. Beyond allowing for simple fabrication, the structural flexibility of conducting polymer materials allows seamless integration into existing experimental setups commonly used in biomedical research Their transparency and tunable optical properties make most conductive polymers conducive to various forms of microscopy. There will be a focus on specific applications of organic bioelectronics in neuroscience, infection research and cell biology
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
