Organelle Segregation and Quality Control during Meiotic Differentiation

Abstract

Meiotic differentiation is a complex developmental program that involves extensive cellular remodeling. In budding yeast, under nutrient deprived conditions, a diploid mother cell undergoes two successive meiotic divisions to generate four nuclei. After meiosis, the four nuclei are packaged with a subset of the organelles and cytoplasm originating from the mother to form four haploid gametes. Our lab has found that during the latter process, certain components of the mother cell are not inherited by the gametes and are subsequently produced de novo. For example, the nuclear pore complexes and components of the nucleoli do not segregate with any of the four nuclei, whereas only a subset of the mitochondria is inherited by the gametes. A programmed pathway that entails vacuole permeabilization subsequently degrades the excluded cellular materials. We posit that the restricted inheritance of organelles and other cellular sub‐compartments is required for cellular rejuvenation that occurs as part of gametogenesis.Support or Funding InformationPew Charitable Trusts (00027344), Damon Runyon Cancer Research Foundation (35‐15), March of Dimes (5‐FY15‐99), National Institute of Health (DP2 AG055946‐01) and Glenn Foundation for Medical ResearchThis abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.