Abstract
When one person wants to communicate securely with another, he/she should contact the other person directly. This rule applies not only to human society, but also to the intracellular micro-society. In the past two decades, it has become increasingly clear that the sub-organelle regions called membrane contact sites (MCSs) are pivotal for inter-organelle transport of lipids in cells, as highlighted in the thematic review series "Interorganelle trafficking of lipids" held in Traffic in 2014-2015. In this commentary, we will describe how the currently prevailing model for lipid trafficking at MCSs was generated, and comment on three important issues that have not been explored: (a1) the principles guiding the generation of an asymmetrical inter-organelle flow of lipids in cells, (b2) the advantages in lipid trafficking at organelle contacts, and (c3) the dynamic network of inter-organelle lipid trafficking.
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