Organelle biogenesis and autophagy

Abstract

Is mitochondrial volume maintained during polarized cell growth? How well do cells ensure that they maintain uniform organelle distribution when they undergo polarized cell growth and subsequent division. S. Rafelski from the Marshall laboratory at University of California–San Francisco used three-dimensional, computationalmodeling methods to demonstrate that mitochondrial volume is maintained during yeast budding through a balance of partial mitochondrial inheritance from the mother and further mitochondrial biogenesis in the daughter. These data demonstrate that cells are systematically maintaining their mitochondrial volume.