Abstract

Organ transplantation is a new issue in medical science. It is an important achievement and a sign of the progression and ability of medical centers around the world. Governments, populations, the medical community and people involved in culture, art, and media all have a decisive role in the culture of organ donation, which is the only way to guarantee that the healthy organs of a brain-dead person can continue to work and save the lives of people in need of organ transplantation. The brain death phenomenon and its possible application in organ transplantation, while offering new hope for the salvation of a number of patients, has led to many ethical, cultural, and legal issues. Ethical issues in organ transplantation are very complicated due to many social factors such as religion, culture, and traditions of the affected communities. The ethical and legal points of removing organs from the body of a living or cadaveric source, the definition of brain death, the moral and legal conditions of the donor and the recipient, and the financial relationship between them and many others, are all critical issues in organ transplantation. While there may be no available explicit solution to these issues, they should be rigorously considered by the experts. Efforts to systematically eliminate barriers and solve problems in organ transplantation, can not only reduce the costs of maintaining brain-dead patients and encourage patients that need organ transplantation but can also prevent immoral and illegal activities. In this paper, we have reviewed the most important and current challenges in organ transplantation with a view to the ethical considerations, and we have suggested some strategies to extend it in Iran.

Highlights

  • Around the world, organ transplantation has been conducted successfully for over 60 years.In Iran, good progress in organ transplantation has been made in recent decades, including organ transplantation from a living or cadaveric source and the presence of transplant centers

  • Organ transplantation is the best cure for these complications [2,3]

  • Brain death is defined as the irretrievable loss of all functions of the brain, including the brainstem [4,5,6]

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Summary

Introduction

Organ transplantation has been conducted successfully for over 60 years. The brainstem is generally spared, whereas the grey and white matters of both cerebral hemispheres are extensively and severely damaged. In a permanent vegetative state (such as months after non-traumatic or one year after traumatic brain damage), brain metabolism values drop to 30–40% of the normal range of values [21]. These characteristics are not evident in every patient

Overview of Organ Transplantation from a Living Donor and a Brain-Death Donor
Risks Associated with Living-Organ Donation
Golden Time in Brain Death for Organ Transplantation
Brain Death and Organ Transplantation Culture in Iran
Challenges Related to Ethical Considerations in Organ Transplantation
Strategies for the Extension of Organ Transplantation in Iran
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