Abstract
ObjectiveTo evaluate organ dose and total effective dose of whole-body low-dose CT (WBLDCT) performed on different CT-scanner models in patients with multiple myeloma (MM) and to compare it to the effective dose of radiographic skeletal survey and representative diagnostic CTs.Material and methodsWe retrospectively analyzed data from 228 patients (47.4% females, mean age 67.9 ± 10.4 years, mean weight 81.8 ± 22.4 kg) who underwent WBLDCT for the work-up or surveillance of MM. Patients were scanned using one of six multi-detector CT-scanners. Organ doses and total effective doses per scan were calculated using a commercially available dose-management platform (Radimetrics, Bayer Healthcare, Leverkusen, Germany). The median effective dose was compared to radiographic skeletal survey and representative diagnostic CTs.ResultsThe mean effective dose of our WBLDCT-protocol was 4.82 mSv. A significantly higher effective dose was observed in females compared to males (4.95 vs. 4.70 mSv, P = 0.002). Mean organ dose ranged from 3.72 mSv (esophagus) to 13.09 mSv (skeleton). Mean effective dose varied amongst different CT-scanners (range 4.34–8.37 mSv). The median effective dose of WBLDCT was more than twice the dose of a skeletal survey (4.82 vs. 2.04 mSv), 23% higher than a diagnostic contrast-enhanced chest CT (3.9 mSv), 46% lower than a diagnostic contrast-enhanced abdomen/pelvis CT (9.0 mSv), and 45% lower than a lumbar spine CT (8.7 mSv).ConclusionsWBLDCT in MM has a higher effective dose than a radiographic skeletal survey, but a lower effective dose than diagnostic CTs of lumbar spine, abdomen and pelvis. This underlines the broad applicability of WBLDCT in the management of MM patients.
Highlights
Multiple myeloma (MM) is the second most common hematological malignancy with an incidence that has risen over the past decades [1, 2]
Our study showed that whole-body low-dose computed tomography (CT) (WBLDCT) in MM patients has a higher effective dose than that of a radiographic skeletal survey, but a lower effective dose than that of diagnostic CTs of the lumbar spine, abdomen and pelvis
According to the most recent International Myeloma Working Group (IMWG) diagnostic criteria, lesions measuring 5 mm on CT or magnetic resonance imaging (MRI) are included in the diagnostic criteria of MM [4], and it is of clinical importance to detect bone involvement in MM and its precursors
Summary
Multiple myeloma (MM) is the second most common hematological malignancy with an incidence that has risen over the past decades [1, 2] It is characterized by the abnormal proliferation of monoclonal plasma cells in the bone marrow, which can lead to replacement of normal myelopoiesis, bone destruction and bone marrow failure [3]. Cross-sectional imaging techniques such as computed tomography (CT), magnetic resonance imaging (MRI) and integrated positron emission tomography/CT (PET/CT), have proven to be more accurate in detecting osteolytic and marrow replacing lesions as compared to skeletal surveys using radiographs [8,9,10,11,12,13,14]. More accurate diagnosis, staging and follow-up of MM is possible [8, 9]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
