Abstract
A 5-year-old boy was referred with local orbital extension of unilateral retinoblastoma (Fig A) and measurable plasma cell-free RB1 DNA (Fig B, magnetic resonance imaging [MRI]). Two years prior he had received 2 courses of systemic chemotherapy with Carboplatin, Vincristine and Etoposide but additional treatment was halted because of a war in his country. Thirteen months later, after 3 sessions of ophthalmic artery chemosurgery with Melphalan, Carboplatin, and Topotecan at our institution, there was complete resolution of the tumor (Fig C) and disappearance of cfDNA (Fig D, MRI).
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