Abstract
BackgroundOrbital mucormycosis is a rare but potentially severe and troublesome invasive fungal infection that could be occurred even in healthy individuals. The initial clinical presentation is similar to bacterial pre-septal or septal cellulitis, especially in early stages.Case presentationHerein, we describe the successful management of a series of five cases presenting with orbital mucormycosis in previously healthy children.ConclusionsOrbital mucormycosis is extremely rare in healthy children and maybe life-threatening when diagnosis delayed given a similar clinical presentation with bacterial septal cellulitis. Intravenous antifungal therapy with amphotericin B and timely surgical drainage is live-saving.
Highlights
Mucormycosis is the third most common invasive fungal infections following candidiasis and aspergillosis [1]
Invasive forms of mucormycosis have been described and well-known in immunocompromised hosts, such as bone marrow transplantation (BMT), aggressive immunosuppressive therapy in hematological malignancies and diabetic patients [3, 13,14,15], it is scarce in healthy individuals [2, 3, 8,9,10,11, 16]
Based on a retrospective global analysis of 101 cases of mucormycosis in France reported by Lanternier et al, all except one have underlying risk factors [17]
Summary
Mucormycosis is the third most common invasive fungal infections following candidiasis and aspergillosis [1]. Discussion and conclusion we report orbital mucormycosis in five immunocompetent children without underling disease or known immunodeficiency successfully managed with medical and surgical interventions.
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