Abstract
Purpose: To report a retro-orbital localization of Multiple Myeloma (MM) describing its treatment and clinical result. Case report: A 50-years-old male patient with Magnetic Resonance Imaging (MRI) evidence of a retro-orbital mass with exophthalmos, due to the pathological diagnosis of MM, was referred for Radiation Therapy (RT). Discussion: The orbital involvement in Multiple Myeloma is rare and few cases are reported in the literature. The treatment of choice is RT alone with a prescribed dose ranging between 40 Gy and 45 Gy. In our patient the retro-orbital lesion, measuring 26 × 16 mm, was treated with Intensity Modulated Radiotherapy Technique (IMRT) delivering 4400 cGy with conventional fractionation. The treatment was well tolerated, the patient experienced a complete regression of the exophthalmos without any significant side effect.
Highlights
The orbital involvement in Multiple Myeloma is rare and few cases are reported in the literature
Multiple Myeloma (MM) is a monoclonal proliferation of plasma cell that causes destructive skeletal lesions and secondary systemic effects, and is a systemic disease diagnosed in the presence of light chain (Bence Jones) proteinuria, lytic skeletal lesions, and characteristic pathology
We report the case of a 50-year-old man who presented right exophthalmos with Magnetic Resonance (MRI) evidence of a retro-orbital mass and with a clinical and pathological history of MM
Summary
Multiple Myeloma (MM) is a monoclonal proliferation of plasma cell that causes destructive skeletal lesions and secondary systemic effects, and is a systemic disease diagnosed in the presence of light chain (Bence Jones) proteinuria, lytic skeletal lesions, and characteristic pathology. It accounts for about 10% of the hematological malignancies, with an incidence of 5.5 cases per 100,000 inhabitants [1]. We report the case of a 50-year-old man who presented right exophthalmos with Magnetic Resonance (MRI) evidence of a retro-orbital mass and with a clinical and pathological history of MM
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