Orally taking paracetamol, celecoxib, and tramadol for analgesia after cesarean section

Abstract

Objective To explore the analgesic effects and side effects of compare the of orally taking paracetamol, celecoxib, and tramadol for analgesia versus patient-controlled epidural analgesia versus patient-controlled intravenous analgesia with morphine after cesarean section under combined spinal-epidural anesthesia. Methods One hundred and fifty women undergoing cesarean section under elective combined spinal-epidural anesthesia at Yongzhou Central Hospital were randomly divided into an oral group, a PCEA group and a PCIA group, 50 for each group. The oral group orally took paracetamol, celecoxib capsules, tramadol extended-release tablets for analgesia, the PCEA group took analgesia with patient-controlled epidural analgesia pump, and the PCIA group took analgesia with patient-controlled intravenous analgesia pump with morphine. The visual analogue scale (VAS score) was used to record pain scores during rest, activity, and the massage of the uterus within 3 days after operation. The time for off-bed activity, analgesia-related side effects, hospital stay, maternal satisfaction, and analgesia cost were recorded. Results During rest, activity, and the massage of the uterus 1 and 2 days after operation, there were no statistical differences in the VAS scores between the oral group and the PCEA group (P> 0.05) ; and the VAS scores of the oral group and the PCEA group were lower than those of the PCIA group (P 0.05) . Fewer patients occurred analgesia-associated adverse events, the time for off-bed activity was shorter, and the score of satisfaction was higher in the oral group than in the PCEA group and the PCIA group (P <0.05) . Conclusions Orally taking paracetamol, celecoxib, and tramadol for analgesia after cesarean section under combined spinal-epidural anesthesia is as effective as patient-controlled epidural analgesia and more effective than patient-controlled intravenous analgesia with morphine, can take off-bed activity earlier, and has lower incidence of analgesia-associated adverse events and cost and higher maternal satisfaction. Key words: Cesarean section; Paracetamol; Celecoxib; Tramadol; Ease pain