Abstract
Orally disintegrating tablets (ODTs) are solid single-unit dosage forms that are designed tobe placed in the mouth, allowed to disperse or dissolve in the saliva, and then swallowedwithout the aid of additional water. Despite a surge of orally disintegrating tablets in themarket in the recent years, they potentially can be confused with other solid oral dosageforms that are consumedwithout additional water intake, including lozenges, buccal tablets,and chewable tablets. Lozenges and buccal tablets are intended to dissolve slowly in themouth,whereas, orally disintegrating tabletsmust disperse or dissolve in themouth quickly,within seconds. Chewable tablets are also different from orally disintegrating tabletsbecause they require manual chewing action by the patients before they can be swallowed.The disintegration times are longer for the chewable tablets compared to the orally dis-integrating tablets. For a tablet to be classified as an orally disintegrating tablet the dis-integration time should be sufficiently rapid for the patient to not feel the need orcompulsion to chew. Orodispersible tablets (1), rapidly disintegrating tablets (2), and fast-dissolving tablets (3) have been used as synonyms for orally disintegrating tablets.Examples of orally disintegrating tablets include over-the-counter drugs such as Claritin
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