Oral Versus Transdermal Estrogen for Uterine Maturation in Girls with Turner Syndrome

Abstract

Background: Turner syndrome (TS) is a genetic disorder caused by the absence of a part or whole X-chromosome with an estimated prevalence of 25-50/100,000 females. The predominant gynecologic manifestation of TS is primary ovarian insufficiency (POI) and inadequate development of secondary sexual characteristics and uterine size. Although uterine growth to allow for future spontaneous pregnancy or embryo transfer is an important goal of care for girls with TS, the optimal method of estrogen delivery and dosing for uterine maturation is unknown.