Oral Versus Intravenous Ibuprofen: Which Is Better in Closure of Patent Ductus Arteriosus?

Abstract

To the Editor. — We read with great interest the article by Cherif et al,1 in which the authors compared the efficacy and tolerance between oral and intravenous ibuprofen in early closure of patent ductus arteriosus (PDA) in very low birth weight (VLBW) infants. They concluded that the rate of early ductal closure with oral ibuprofen was at least as good as with the intravenous route in VLBW infants and was associated with fewer adverse effects. In Turkey, we have been using oral ibuprofen in closure of PDA successfully for many years because of the unavailability of intravenous …