Abstract
Verrucous carcinoma (VC) is an unusual, well differentiated, and low-grade type of squamous cell carcinoma, characterized by benign histology and cytology but markedly invasive clinical behavior. They have a predilection for squamous mucosae, particularly those of the head and neck region. Many factors have been associated with its pathogenesis, including the presence of previous skin lesions; VC arising from a prosthesis injury is rare. Here we reported a case of VC of oral cavity a particularly very aggressive, arising from prosthesis injury. Regardless of the treatment modality, given new insights into the possible aggressivity of this tumor, radiotherapy associated to chemotherapy may be a more appropriate primary treatment compared with the significant local morbidity associated with surgery.
Highlights
The Verrucous Carcinoma was described by LV Ackerman in 1948 as an infrequent subtype of malignant disease of the oral cavity [1]
The etiology and pathogenesis of Oral verrucous carcinoma (OVC) are not clear, though there is a strong association with the use of tobacco, alcohol, and poor oral hygiene [3]
We report a case aggressive complicating a repetitive injury by the dental prosthesis
Summary
The Verrucous Carcinoma was described by LV Ackerman in 1948 as an infrequent subtype of malignant disease of the oral cavity [1]. She was presented with a 4month history of a painless growing tumor of the hard palate, associated to left-sided otalgia and subjective left-sided hearing loss. She didn't have any vertigo, headaches, or vision changes. The head and neck CT showed (Figure 3) tissue thickening of the hard palate extended to the floor of the nasal cavity, with lysis of the maxillary sinus and extension to the masseter muscle, the nasopharynx and infratemporal fossa .The tumor is associated with submandibular nodes and upper internal jugular nodes. The control head and neck CT showed disappearance of nodes enlargement but with the same extension of the tumor There was neither local recurrence nor distant metastasis observed for six months
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