Abstract
To ensure the safety of trypanocidal molecules of thiosemicarbazones hemi-synthesized in essential oil of Cymbopogon citratus , toxicology studies were conducted. These studies which were performed on rats “Wistar” had focused on our most active molecules: citral thiosemicarbazone, citral semicarbazone, citral 4-phenylthiosemicarbazone and the starting substrate which was the essential oil of Cymbopogon citratus . From these studies, it appears that citral semicarbazone, citral 4-phenylthiosemicarbazone and essential oil were no toxic as LD 50 > 2000 mg/kg. Citral thiosemicarbazone was slightly more toxic with a LD 50 = 315 mg/kg. The study of biochemical parameters revealed that the use of a high dose of the compounds may affect kidney function. A strong dose of essential oil of Cymbopogon citratus could affect liver function. It appears that the citral 4-phenylthiosemicarbazone is a very promising compound because it had an excellent antitrypanosomal activity and had very low toxicity (IC 50 = 1.96 μM; LD 50 > 2000 mg/kg). © 2019 International Formulae Group. All rights reserved. Keywords: Trypanocidal thiosemicarbazones, toxicology, essential oil, Cymbopogon citratus , biochemical parameters
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