Oral Supplementation with l-Cystine, Serenoa repens, Cucurbita pepo, and Pygeum africanum in Chronic Telogen Effluvium and Androgenetic Alopecia: A Double-Blind, Placebo-Controlled, Randomized Clinical Study

Abstract

Plain Language SummaryChronic telogen effluvium and androgenetic alopecia are two common types of hair loss that can have a significant impact on individuals’ quality of life. Research suggests that deficiencies in essential micronutrients may play a role in hair loss. To investigate this further, a study was conducted to assess the effectiveness and safety of an oral supplement containing l-Cystine, Serenoa repens, Cucurbita pepo, Pygeum africanum, as well as vitamins and micronutrients, in treating these conditions. The study involved 80 participants aged 18 to 60, both male and female, who were diagnosed with these types of hair loss. They were randomly assigned to take either the oral supplement or a placebo daily for 6 months. Throughout the study period, participants underwent dermatological evaluations, clinical photography, and phototrichograms to monitor changes in their hair. They also completed standardized questionnaires to assess their subjective experience of hair growth and appearance. Results showed that participants who took the oral supplement experienced a significant increase in hair density compared to those who took the placebo, with improvements observed as early as 3 months into the study. Additionally, the overall volume and appearance of their hair showed noticeable enhancement. Importantly, the oral supplement was well-tolerated, with no reports of moderate or severe adverse effects. In conclusion, the findings suggest that this oral supplement could be a safe and effective treatment option for individuals with chronic telogen effluvium or androgenetic alopecia, offering improvements in hair density and overall appearance.