Abstract
Oral squamous cell carcinoma represents more than 90% of all oral cancers. Ten percent of the cases are found on the buccal mucosa and the gingiva. The World Health Organization defines a premalignant or precancerous lesion as a morphologically altered tissue in which cancer is most likely to occur and includes oral leukoplakia, oral erythroplakia, and possibly oral lichen planus (OLP). The purpose of this study was to discuss the possibility of malignant transformation of OLP. The potency of OLP as a premalignant lesion is still an ongoing controversial discussion in literature. The report a case of oral squamous cell carcinoma located on the left buccal mucosa accompanied by oral lichenoid lesions on the right buccal mucosa, lower labial mucosa, and left buccal mucosa. These findings led to a possibility of malignant transformation of the oral lichenoid lesion. Unfortunately, biopsy on the lichenoid lesions was not performed. Therefore, a definitive diagnosis of OLP could not be established and the possibility of the lesions being dysplastic remained unclear. This study concluded that biopsy is mandatory to establish a definitive diagnosis of OLP and to investigate the possibility of dysplasia. It is necessary to perform examination of genetic alteration in dysplastic OLP in order to assess loss of heterzygosity (LOH), which may help to consider the risk of malignant transformation.
Highlights
Oralsquamoucsellcarcinomarepresenmtsorethan90%ofall oralcancersT.enpercenot f th€casesare foundon the buccalmucosaand the gingiva.The World HealrhOrganizationdefinesa premalignanotr precanceroulessionasa morphologicallaylleredtissuein whi€hcanceris morelikelyro occurandincludes oralleukoplakiao,raler),throplakia,ndpossiblyorallichenplanus(OLP).Thepurposeof thisstudywasto discussthepossibilityof malignanttransformatioonfOLP
ThepotencyofOLP asa premalignanlet sionis still an ongoilg controversialdiscussionin the literature.The repor(a caseof oral squamouscell carcinoma locatedon lhe lefi buccalmucosaaccompaniebdy oral lichenoidlesionson rherightbuccalmucosal,ower labialmucosaa, ndleft buccalrnucosaT. hesefindingsledto a possibilityofmalignant ransformatioonfthe oral lichenoidlesions.Unfortunatelyb, iopsyon the lich€noidl€sionswas not performed.Therefor€a, d€finitiv€diagnosisof oml tidak ada kclainan.Kelenjar limfe p/drrs (OLP) could not be esrablisheadod the possibiliryof the lesionsbeingdysptastic remain€dunclearT. his studyconcludedtharbiopsyis mandatortyo establisha definitivediagnosisofol-p andto investigattehepossibilityofdysplasiaI.r is necessartyo performexaminatioonfgeneticalterationisn dysplasticOLP in orderto assesslossof heterozygosit(yLOH), which may help to considerthe risk of malignanttransformationln.donesiaJnounal ofDentistry2006:EdisiKhuus KPPIKGXIy:[353-357]
Kim HS fvdluarionoi Prcmalignanr Potentialin Oral Lichen PlanusUsing lnterphase
Summary
Karsinomaronggamulutmerupakasnalahsatu ami perubahanrnorfologik yang memungkinkan darib€rbagakiankeryangseringte4adidi duniadan terjadinyakanler.Lesirersebumt €lipurileukolakia, 90%di antaranyadalahkarsinomaselskuamosa.r? eritroplakiadan mungkin juga lichen planus.l. Karsinomas€l skuamosadapatterjadi padabibir Selamaini kemungkinanlichen planus sebagailesi (2s-30%),lidah Q-aj%), dasa(mulut (15-20%), pra keganasanrnasih n€rupakan perd€baran.rr mukosabukaldangingiva(10%)danpadapalalum Dalam literaturdisebutkanbahwa lichen planus (10-20%).'Karsin-ornsael skuamosaseringterjadi mempunyaipotensi sebagail€si pra keganasan padar.rsialanjut' dan rerdaparpredilelsi pada dengankemungkina
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