Abstract
Fanconi anemia (FA) is an autosomal recessive disorder with the following important features: (1) progressive bone marrow failure and (2) development of malignancies. We report 2 cases of oral squamous cell carcinoma in male patients with FA who underwent hematopoietic stem cell transplantation. Both patients presented with oral lichenoid lesions, compatible with chronic graft vs host disease. In the first case, a 16-year-old patient presented with an extensive infiltrative and necrotic lesion on the border of the tongue. After biopsy, the diagnosis of squamous cell carcinoma was confirmed. The patient received chemotherapy and radiotherapy but died 4 months later. In the second case, a 26-year-old patient presented with an irregular white plaque on the border of the tongue. After histopathologic diagnosis confirmation, the carcinoma was surgically resected and the patient is under follow-up evaluation. Patients with FA have a high risk for oral cancer and their systematic follow-up is essential.
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