Abstract
Spindle cell lipoma is an histological type of lipoma which are rarely found in the oral cavity. We describe two cases of intraoral spindle cell lipomas. The pa- tients were men and presented painless slow growing masses in the left cheek and hard palate, measuring 50 × 30 mm and 23 × 20 mm respectively. Microsco- pically, both lesions presented a solid proliferation of mature fat cells intermixed with bundles of connec- tive tissue. Cells were immunopositive for S100 pro- tein and CD34 (one case), with low mitotic activity (Ki-67). The final diagnosis was spindle cell lipomas. The lesions were excised and no recurrence was no- ticed after six months. Oral spindle cell lipomas are unexpected to occur in the oral mucosa, and the main differential diagnosis is well-differentiated liposar- coma/atypical lipoma. Lesions are treated with sur-gical excision and recurrences are rare.
Highlights
Lipomas are the most common soft tissue neoplasms; the oral cavity is affected less frequently
Spindle cell lipoma is an histological type of lipoma which are rarely found in the oral cavity
We describe two cases of intraoral spindle cell lipomas
Summary
Lipomas are the most common soft tissue neoplasms; the oral cavity is affected less frequently. According to the microscopic features, lipomas can be classified as conventional lipomas, fibrolipomas, angiolipomas, myxoid lipomas, sialolipomas, intramuscular lipomas, spindle cell/pleomorphic lipomas (SCPL), myolipomas, or chondroid lipomas [1,2,3]. Since the first report of an intra-oral SCPL, 23 new cases have been well documented [1,2,4,5,6,7,8,9]. We describe clinical and histological features of two new cases of intra-oral SCPL, and discuss the characteristics of this rare entity
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