Abstract
A 54-year-old female patient with previous diagnosis of untreated discoid lupus erythematosus presented a 3-month history of labial nodular growths. This patient reported a previous injury on the nose, with the diagnosis of granulomatous dermatitis. Physical examination revealed multiple, firm, sessile, and normochromic labial nodules with approximately 2.0 × 3.0 cm. An incisional biopsy was performed and histopathologic examination revealed a fibrous connective tissue containing non-caseating compact granulomas that invaded the skeletal muscle and preserved nerve bundles. Grocott and Wade Fite staining were negative and the histopathologic finding was suggestive of sarcoid granulomas. Other laboratory tests were performed and supported this diagnosis (serum levels of angiotensin converting enzyme, immunoglobulins, alkaline phosphatase, calcium, urinary calcium, Montenegro's reaction, thoracic computed tomography, creatinine, and complete blood count). Before initiation of treatment, the lesions spontaneously regressed, and a follow-up at 18 months showed no recurrence.
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