Abstract
Plasmablastic lymphoma (PBL) is a rare variant of large diffuse B-cell non–Hodgkin lymphoma with predilection for extranodal localization in the oral cavity. A 43-year-old HIV-positive female patient attended a stomatology service for evaluation of a painful oral mass with 6 months of duration. At the extraoral examination, swelling in the left hemiface and facial increased lymph nodes were present. Intraorally, a purplish red exophytic sessile nodule presenting indefinite borders and an ulcerated surface was found. Areas of necrosis were observed at the upper alveolar ridge, palate, and left buccal mucosa, and adjacent teeth were mobile. The clinical impression was a malignant neoplasm, and the patient was submitted to an incisional biopsy. The histopathologic and immunohistochemistry were consistent with a PBL. The patient was referred to the hematologic service and submitted to DA-EPOCH chemotherapy. After 3 months of follow-up consultations, partial remission of the lesion without considerable systemic or oral intercurrences was observed.
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